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PUFF-PLUME is a Gaussian atmospheric transport chemical/radionuclide atmospheric dispersion model that includes wet and dry deposition, real-time input of meteorological observations and forecasts, dose estimates from inhalation and gamma shine (i.e., radiation), and puff or plume dispersion modes.

It is the primary model for emergency response use for atmospheric releases at the United States Department of Energy's nuclear material processing activities at their Savannah River Site in South Carolina. It is one of a suite of codes for atmospheric releases and is used primarily for preliminary results in emergency situations. (Other codes containing more detailed mathematical and physical models are available for use when a short response time is not the over-riding consideration.)

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